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CCT 068127
CAS No. 660822-23-1
CCT 068127( CCT68127 | CCT 68127 )
Catalog No. M15513 CAS No. 660822-23-1
CCT 068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
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| 50MG | 1782 | Get Quote |
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| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCCT 068127
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NoteResearch use only, not for human use.
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Brief DescriptionCCT 068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively.
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DescriptionCCT 068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively; also inhibits CDK5/p35, CDK2/A, CDK7/H with IC50 of <1 uM, but without significant activity against ABL, AKT, CAMKII, CK2, ERK2, GSK3 etc.; causes a dramatic loss in expression of DUSP6 phosphatase, alongside elevated ERK phosphorylation and activation of MAPK pathway target genes in cancer cells.
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In Vitro——
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In Vivo——
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SynonymsCCT68127 | CCT 68127
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number660822-23-1
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Formula Weight369.473
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Molecular FormulaC19H27N7O
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@@H](O)[C@@H](NC1=NC(NCC2=CC=CN=C2)=C3N=CN(C(C)C)C3=N1)CC
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Chemical Name(2R,3S)-3-((9-Isopropyl-6-((pyridin-3-ylmethyl)amino)-9H-purin-2-yl)amino)pentan-2-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Whittaker SR, et al. Mol Oncol. 2017 Oct 24. doi: 10.1002/1878-0261.12148.
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