CCT 068127 ( CCT68127;CCT 68127 )

Catalog No. M15513 CAS No. 660822-23-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CCT 068127
Note

Research use only, not for human use.
Brief Description

CCT 068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively.
Description

CCT 068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively; also inhibits CDK5/p35, CDK2/A, CDK7/H with IC50 of <1 uM, but without significant activity against ABL, AKT, CAMKII, CK2, ERK2, GSK3 etc.; causes a dramatic loss in expression of DUSP6 phosphatase, alongside elevated ERK phosphorylation and activation of MAPK pathway target genes in cancer cells.
Synonyms

CCT68127;CCT 68127
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

660822-23-1
Formula Weight

369.47
Molecular Formula

C19H27N7O
Purity

>98% (HPLC)
Solubility

——
SMILES

C[C@@H](O)[C@@H](NC1=NC(NCC2=CC=CN=C2)=C3N=CN(C(C)C)C3=N1)CC
Chemical Name

(2R,3S)-3-((9-Isopropyl-6-((pyridin-3-ylmethyl)amino)-9H-purin-2-yl)amino)pentan-2-ol

1. Whittaker SR, et al. Mol Oncol. 2017 Oct 24. doi: 10.1002/1878-0261.12148.

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